Top Articles at IgMin Research

Nanotechnology, particularly nanorobotics, has emerged as a transformative force in modern medicine. Nanorobots, designed at the molecular scale, hold promise for a range of medical applications, including targeted drug delivery, early disease diagnostics, minimally invasive surgeries, and precise infection control. Their unique ability to interact with biological systems at the cellular level opens avenues for significant advancements in treatment protocols, potentially overcoming current limitations in traditional therapies. This review delve...s into the development, mechanisms, and diverse medical applications of nanorobots, highlighting their structural components, energy sources, and propulsion methods. Additionally, we explore specific case studies in cancer treatment, infection control, and surgical innovations, assessing both the advancements and challenges associated with nanorobotic technologies. The goal is to present a comprehensive overview that underscores the potential of nanorobots to revolutionize patient care and set the stage for future research in this burgeoning field.Read more

The astronomical theory of ice ages is widely accepted. Yet, it is not abundantly clear just exactly what the astronomical theory of ice ages is, other than the vague statement that variations in the Earth's orbit produce changes in solar irradiance at northern latitudes which is somehow related to the formation and termination of ice ages. Periodic variations in the Earth’s orbit produce variations in the insolation at high latitudes and ice ages begin on down lobes of insolation and terminate on up lobes of insolation. However, not all ...down lobes create ice ages and not all up lobes produce terminations. The ice ages changed character at the so-called mid-Pleistocene transition, about a million years ago. There is no current physical explanation for these difficulties with the astronomical theory. A reasonable explanation has been developed, that solidifies the astronomical theory by explaining the rise and fall of ice ages in both eras. The solar power absorbed at high northern latitudes depends on the insolation and absorptivity of the surface. The absorptivity is particularly affected by the obliquity in the pre-MPT era, and by dust deposits late in the post-MPT era. When these are included, it can be explained why some down lobes produce ice ages, and some up lobes produce terminations in both eras. In the pre-MPT era, ice ages originate when the insolation enters a down lobe and the obliquity is minimal (higher reflectivity) and ice ages terminate at a coincidence of high insolation and high obliquity (lower reflectivity). These links between SIHL and obliquity tend to be repetitive with approximately 41,000-year spacing. In the post-MPT era, ice ages also originate at a down lobe of SIHL. However, once an ice age is started, each successive up lobe in SIHL might cause a slight decrease in ice volume but doesn’t bring about a termination. After several precession cycles, high dust levels increase absorptivity, and the next-up lobe produces a termination.Read more

The study evaluates the efficacy of leufenuron, emamectin benzoate, and thiamethoxam against the Dusky Cotton Bug (Oxycarenus laetus Kirby) using residue-based bioassay methods. Key findings indicate that emamectin benzoate showed the highest efficacy with the lowest LC50 value, making it the most potent insecticide among those tested. Leufenuron and thiamethoxam followed, displaying moderate effectiveness. The results highlight the comparative advantages of emamectin benzoate in controlling Dusky Cotton Bug populations, suggesting its potentia...l role in integrated pest management strategies. This study underscores the need for environmentally friendly alternatives to traditional insecticides in mitigating yield losses in cotton production.Read more

The Aral Sea is located in the heart of Asia, in Central Asia, spanning the western part of Kazakhstan and the northwestern part of Uzbekistan. It is a transient lake that emerged in its current location approximately 600–700 years ago. Until the 1960s, the surface level of the Aral Sea continued to rise due to the inflow from the Amu Darya and Syr Darya rivers.

Since the initial identification of TBCK (formerly MGC16169) in 2010, significant advances have been made in understanding the role of TBCK mutations in neurodevelopmental disorders such as TBCK encephalopathy. However, the precise function and detailed mechanisms of TBCK remain largely unexplored. Previous studies, including our own, suggest that aberrant expression or mutations in TBCK can impact cell growth, division, and cytoskeleton assembly, contributing to both cancer and neurogenetic diseases. Despite this, the specific domains within T...BCK responsible for these functions are still unclear. Notably, mutations in the TBC domain have been implicated in disrupting mTOR pathways, linking TBCK dysfunction to neurogenetic disorders and cancers. Given TBCK’s diverse roles, we have focused on its putative kinase domain. Through comprehensive analysis using tools such as Kinase Tree, AlphaFold2, Clustal Omega, and SMART, we discovered that TBCK lacks the key “D” residue in the conserved “HRD” and “DFG” motifs typical of protein kinases like PKA and SRC, suggesting TBCK functions as a pseudokinase. Intriguingly, gene ontology analysis from recent RNA-seq data indicates TBCK’s involvement in regulating protein phosphorylation. This suggests that TBCK may influence protein phosphorylation either directly through its potential kinase domain or indirectly via interactions with other proteins. To uncover the full spectrum of TBCK’s roles in neurogenetic disorders and cancer, urgent high-throughput analyses are necessary to identify its interacting partners.Read more

Recently, environmental pollution has acquired the character of a global environmental threat, the current situation causes concern for the authorities, scientists, and the public and the need to develop simple and sufficiently effective technologies for the return to nature of elements that have been re-formed in the course of economic processes and thus become pollutants.Traditionally used physical and chemical methods are effective, but very expensive and may cause additional load on ecosystems. Existing outdated technologies and equipment f...or wastewater treatment need to be replaced with new ones.Phytoremediation is a set of methods for treating wastewater, soil and atmospheric air with the help of green plants. Due to differences in plant physiology, not all plants can collect heavy metals or organic pollutants. Even varieties of the same species can accumulate pollutants.The work aims to investigate natural means of cleaning the environment by phytoremediation.Several field trials confirmed the possibility of using the Paulownia plant for cleaning the air environment of Almaty city. The results of the study showed that the fast-growing Paulownia tree in areas with heavy metal-contaminated cadmium, lead, arsenic and antimony polluted and disturbed soils can be rehabilitated or reclaimed.All advantages and limitations of the phytoremediation method were investigated and experimentally demonstrated. The obtained research results confirm the prospects of the phytoremediation method for reducing environmental impact on contaminated soils.Read more

This paper presents a Technical and Economic Feasibility Study of proposed Pumped Storage Power Plants (PSPPs) at KM (Kuda Oya, Mul Oya), KMG (Kuda Oya, Mul Oya, Gurugal Oya), KG (Kuda Oya, Gurugal Oya), and Dambagasthalawa. Sri Lanka aims to transition away from a coal-dominant electricity sector within the next decade, aligning with sustainability goals outlined by the United Nations. In pursuit of affordable and clean energy sustainability, the Sri Lankan government has opted to shift its long-term energy policy towards renewable sources, de...parting from fossil fuels. Despite this shift, a significant portion of Sri Lanka's electricity consumption—approximately 600 MW from oil and 900 MW from coal—persists. The country now aims to source 80% of its energy from renewable sources, necessitating a focus on underutilized opportunities. In selecting the best candidate sites for Pumped Storage Power Plant (PSPP) design, comprehensive hydrological and sedimentation studies play a pivotal role. In this endeavor, we endeavor to re-rank the selected candidate sites for pumped storage power plants considering technical & financial feasibility by conducting comprehensive hydrological and sedimentation studies. These studies are pivotal for assessing the feasibility and long-term viability of potential sites, aiming to select the most sustainable candidate site in every aspect. Therefore, the primary objective of this research is to conduct a thorough hydrologic study of the proposed KMG and Dambagastalawa pump storage power plants, focusing on identifying potential energy-saving opportunities in pumping when these plants operate as open-loop systems. This study will analyze the hydrology of the upper ponds of the Kuda Oya, Mul Oya, and Gurugal Oya (KMG) pump storage power plants, and the Dambagastalawa Oya pump storage power plant, assessing the potential reduction in pumping energy. Such insights are essential for optimizing the design and operation of PSPPs to ensure economic viability and sustainable energy generation. Furthermore, this research addresses the importance of studying sedimentation in both the upper and lower ponds of the KMG and Dambagastalawa pump storage power plants. Sedimentation calculations will be performed to determine reservoir lifetimes, offering critical insights into the long-term feasibility and maintenance requirements of these projects. The findings of this study are expected to provide valuable guidance to policymakers, investors, and PSPP designers in selecting the most suitable sites for addressing Sri Lanka's peak power demands and urgent electricity needs. By emphasizing the significance of hydrological and sedimentation studies, this research underscores the importance of thorough site assessment in optimizing the design and operation of Pumped Storage Power Plants. Read more

The wear behavior in solid metallic materials is of high importance because of its connection with production cost. In this work, the behavior of wear and wear rate is shown in grinding balls produced from high Fe-Cr-C alloys produced by melting in medium frequency induction furnaces, and molding by automatic fleckless molding machine– Disamatic moldings machine. The total testing time is (12 hrs). The abrasive wear rate, which is the wear resistance multiplied by testing time in mg/Kg.hr. Two grinding balls of each of the three alloys: B...C26, BC18, and BC13 are tested by rotating the balls with (50 Kg), cement powder inside a diesel working mixer of circular sections, inclined 45 and rotating by 30 rpm. Weighting and hardness testing results are found in the text, the chemical composition was tested by using spectra analyses type ARL 34000 OE. All the results obtained are shown in the tables and figures in the text. As a result, it can be stated that increasing Cr%, increases hardness, and decreases the wear rate, and the harder and higher the Cr% and C% it contains, the lower the wear rate and the higher wear resistance.Read more

Mastocytosis, a hematological neoplasm, manifests with diverse clinical, molecular, and histomorphological features. This review explores the different subtypes of mastocytosis, focusing on the role of molecular pathology and histomorphology in diagnosing systemic mastocytosis (SM). Systemic mastocytosis is characterized by histologically confirmed extracutaneous involvement, presenting a diagnostic challenge due to its rarity and diverse subtypes, ranging from occult SM to mast cell leukemia. The complexity of accurate SM diagnosis underscores... the necessity for a comprehensive understanding of the disease spectrum. Mastocytosis emerges as a rare, multifaceted disease, predominantly affecting children in the cutaneous form and adults in the systemic variant. The review advocates a multidisciplinary diagnostic approach involving experienced hematopathologists and haematooncologists, employing conventional histomorphology, immunohistochemistry, and molecular techniques. This holistic approach is crucial for accurate diagnosis, especially in light of recent therapeutic advances, particularly the growing importance of tyrosine kinase inhibitors (TKI) in the management of mastocytosis.Read more

Background: There is an increasing focus on communication between doctors and patients, and recent systematic reviews argue that teaching doctors necessary communication skills benefits patients at large. Moreover, patients report the lack of communication as their second-leading complaint. Motivational interviewing has proved to be person-centered in healthcare in communication between patients and doctors.Aim: To examine how being inspired by motivational interviewing theory and using the Calgary Cambridge guide could improve medical students...' communication skills at the master level using a mixed-method approach.Methods: A cohort study with an exposed cohort compared to a non-exposed historical cohort. The participants were students in their sixth year of medical training from the Clinical Department of the University of Southern Denmark. The non-exposed cohort received laboratory training based on the Calgary Cambridge Guide. After this training, they participated in a two-month clinical "stay" and recorded two digital audio files of a real conversation with a patient about delivering information. The exposed cohort followed the same schedule but received additional special training in MI. All audio files were analyzed using the Motivational Interviewing Integrity method (MITI). An additional focus group interview was conducted to support the results.Results: Medical students demonstrated improvements in several essential areas of their communication style favorable to the MI approach, particularly empathy, and person-centeredness. The focus group interviews supported these findings.Read more